Dermatopathology Cases

Cutaneous Leishmaniasis Visit: Dermatopathology site Visit: Pathology of Leishmaniasis Abstract: Molecular characterization of leishmania species isolated from cutaneous leishmaniasis in yemen. PLoS One.2010 Sep 20;5(9). pii: e12879. BACKGROUND: Cutaneous leishmaniasis (CL) is a neglected tropical disease endemic in the tropics and subtropics with a global yearly incidence of 1.5 million. Although CL is the most common form of leishmaniasis, which is responsible for 60% of DALYs lost due to tropical-cluster diseases prevalent in Yemen, available information is very limited. METHODOLOGY/PRINCIPAL FINDINGS: This study was conducted to determine the molecular characterization of Leishmania species isolated from human cutaneous lesions in Yemen. Dermal scrapes were collected and examined for Leishmania amastigotes using the Giemsa staining technique. Amplification of the ribosomal internal transcribed spacer 1(ITS-1) gene was carried out using nested PCR and subsequent sequencing. The seq...

Image1 Image2 Image3 Case 72 Spot diagnosis Answer

Grover's Disease Visit: Dermatopathology site Abstract: Photo Quiz-Pruritic Papules on the Chest and Back:Am Fam Physician. 2006 Aug 15;74(4):641-642. Grover's disease: clinicopathologic review of 72 cases. Mayo Clin Proc. 1999 Mar;74(3):229-34. OBJECTIVE: To report the clinicopathologic findings in patients with Grover's disease. MATERIAL AND METHODS: We reviewed the medical records and biopsy specimens from 72 patients with transient acantholytic dermatosis (Grover's disease) examined at Mayo Clinic Rochester. Hematoxylin-eosin-stained biopsy specimens (from all patients) were assessed. Immunohistochemistry stains BRST-2, CAM 5.2, and CD44 were used to stain eight specimens. Direct immunofluorescence reports were reviewed. Selected specimens were stained by indirect immunofluorescence to detect major basic protein. RESULTS: Of the 72 patients, 63 (88%) were men, and the mean age was 48 years (range, 31 to 85). Lesions were distributed mainly on the trunk (in 71 patien...

Image1 Image2 Image3 Case 71 A 65 year old man with small, pruritic, erythematous papulovesicles on the upper arm. The patient had persistent fever and sweating. He also had a history of bone marrow transplantation. Answer

Special stain: von Kossa stain Cutaneous Malakoplakia Visit: Dermatopathology site Abstract: Perianal cutaneous malakoplakia in an immunocompetent patient. Dermatol Online J. 2010 Jan 15;16(1):10. Malakoplakia is an uncommon inflammatory condition usually affecting the genitourinary tract, which has been associated with infections, tumors, and immunocompromised states. The condition has been reported in many different organs and it may rarely involve the skin. We describe a case of an isolated perianal cutaneous malakoplakia in an immunocompetent 23-year-old Syrian male. [Vesico-cutaneous fistula revealing abdominal wall malakoplakia accompanied by Boeck's sarcoidosis]Orv Hetil.2010 Feb 7;151(6):220-3. Malakoplakia is an acquired granulomatous disorder first described by Michaelis and Gutmann in 1902. The pathogenesis of malakoplakia is hardly known, but it thought to be secondary to an acquired bactericidal defect in macrophages occurring mostly in immunosuppressed patients. CASE...