Answer of Dermatopathology Case 71
Grover's Disease Visit: Dermatopathology site Abstract: Photo Quiz-Pruritic Papules on the Chest and Back:Am Fam Physician. 2006 Aug 15;74(4):641-642. Grover's disease: clinicopathologic review of 72 cases. Mayo Clin Proc. 1999 Mar;74(3):229-34. OBJECTIVE: To report the clinicopathologic findings in patients with Grover's disease. MATERIAL AND METHODS: We reviewed the medical records and biopsy specimens from 72 patients with transient acantholytic dermatosis (Grover's disease) examined at Mayo Clinic Rochester. Hematoxylin-eosin-stained biopsy specimens (from all patients) were assessed. Immunohistochemistry stains BRST-2, CAM 5.2, and CD44 were used to stain eight specimens. Direct immunofluorescence reports were reviewed. Selected specimens were stained by indirect immunofluorescence to detect major basic protein. RESULTS: Of the 72 patients, 63 (88%) were men, and the mean age was 48 years (range, 31 to 85). Lesions were distributed mainly on the trunk (in 71 patien