Dermatopathology Cases

Epithelioid Hemangioendothelioma Visit: Dermatopathology site Visit: Pathology of Hemangioendothelioma Abstract Epithelioid hemangioendothelioma presenting in the skin: a clinicopathologic study of eight cases. Am J Dermatopathol.1998 Dec;20(6):541-6. Epithelioid hemangioendothelioma arising in the skin is extremely rare, and the majority of documented cases have developed in association with an underlying bone tumor. We report eight patients with an age range of 29-84 years (mean 53), who presented with primary cutaneous tumors at a variety of sites including the palm, shin, neck, knee, nose, back, and penis with a duration of between 6 and 12 months. Histologically, all eight cases presented as circumscribed nodules with an overlying acanthotic epidermis, three showing striking acrosyringeal proliferation, reminiscent of eccrine syringofibroadenoma. The tumors were composed of an admixture of slightly pleomorphic spindle and epithelioid cells with abundant, sharply defined eosinophil...

Image1 Image2 Image3 Image4 Image5 Case 98 A 45 year old woman with an erythematous, soft, painful nodule on the neck. Diagnosis

Immunohistochemistry findings: CD3 CD4 CD7 CD20 Mycosis Fungoides-associated Follicular Mucinosis: Abstract: Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides- associated follicular mucinosis.J Cutan Pathol. 2009 Jul 14. Objectives: To determine (i) whether primary (idiopathic) follicular mucinosis (PFM) and lymphoma-associated follicular mucinosis (LAFM) are distinct or related entities and whether there are reliable criteria that allow the two forms to be distinguished, (ii) the histochemical properties and consequently the type of mucin that accumulates in the follicle in PFM and LAFM, and (iii) whether there is any difference between the staining properties of mucin in patients with PFM and LAFM. Methods: Thirty-one patients were divided into two groups. Group 1 comprised 20 patients with no associated mycosis fungoides or Sézary syndrome (PFM) and group 2 was made up of...

Image1 Image2 Image3 Image4 Case 97 A 56 year old woman with violaceous follicular nodules and indurated plaques on the face and neck. Diagnosis

Immunohistochemistry: CD30 positive cells [ CD3 & CD4 are faintly positive ; ALK and EMA -Negative] Primary Cutaneous Anaplastic Large Cell Lymphoma Abstracts: Primary cutaneous anaplastic large-cell lymphoma.Dermatol Online J. 2010 15;16(11):2. Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood.2000 Dec 1;96(12):3681-95. Anaplastic large cell lymphoma (ALCL...