Answer of Dermatopathology Case 96
Immunohistochemistry: CD30 positive cells [ CD3 & CD4 are faintly positive ; ALK and EMA -Negative] Primary Cutaneous Anaplastic Large Cell Lymphoma Abstracts: Primary cutaneous anaplastic large-cell lymphoma.Dermatol Online J. 2010 15;16(11):2. Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood.2000 Dec 1;96(12):3681-95. Anaplastic large cell lymphoma (ALCL