Answer of Dermatopathology Case 61
Targetoid Hemosiderotic Hemangioma (Hobnail Hemangioma) Visit: Dermatopathology site Visit: Targetoid Hemosiderotic Hemangioma (Hobnail Hemangioma) Abstract: Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas.J Cutan Pathol.2004 May;31(5):362-7. BACKGROUND: Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a small benign vascular tumor of the superficial and mid-dermis. In contrast to its well-characterized histology, it has been unclear whether this tumor arises from blood vessel endothelial cells (BECs) or lymphatic vessel endothelial cells (LECs). METHODS: We analyzed 10 hobnail hemangiomas by immunohistochemistry, using the recently described lymphatic endothelial cell marker, D2-40. For comparison, CD31, CD34, and alpha-smooth muscle actin expression were studied in consecutive sections of the paraffin-embedded tissues. RESULTS: In all analyzed vessels, D2-40 labeled exclusively LECs, whereas BECs were consistently negative. In contrast to c