Clear Cell Acanthoma Visit: Pathology of Clear Cell Acanthoma Visit: Dermatopathology site Abstract: Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology ofclear-cell acanthoma . Dermatol Surg. 2009 Jun;35(6):952-9. BACKGROUND: Clear cell acanthoma (CCA) is a rare, benign neoplasm of unknown etiology, whose dermoscopic and histological features have been previously described. Usually, CCA can be diagnosed by clinical and dermoscopic examination. In some cases, diagnosis remains uncertain, and histological examination is needed. The aim of this paper was to describe the features of reflectance confocal microscopy (RCM) in diagnosing CCA, compare them with findings on dermoscopy and histology, and evaluate their possible usefulness in CCA evaluation. PATIENTS AND METHODS: Five lesions diagnosed clinically as CCA were imaged using dermoscopy and RCM. All lesions were surgically excised to confirm the diagnosis and compare the morphological attributes under light mi