Dermatopathology Cases

Immunohistochemistry: CD34 is strongly positive. Dermatofibrosarcoma Protuberans Visit: Dermatopathology site Abstract: Cutaneous CD34+ Spindle Cell Neoplasms: Histopathologic Features Distinguish Spindle Cell Lipoma, Solitary Fibrous Tumor, and Dermatofibrosarcoma Protuberans.Am J Dermatopathol. 2010 Jun 17. Spindle cell lipoma (SCL), dermatofibrosarcoma protuberans (DFSP), and solitary fibrous tumors (SFT) are cutaneous CD34+ spindle cell tumors that may exhibit histopathologic and immunophenotypic overlap. We sought ways to reliably distinguish among these lesions even in small or superficial biopsies. Ten morphologic characteristics were analyzed in a group of 5 SCLs, 6 cutaneous SFTs, and 12 DFSPs. SFT and DFSP exhibited extensive histopathologic overlap in small or partial biopsies. However, adnexal entrapment, defined as diffuse proliferation of tumor cells around pilosebaceous and eccrine structures with minimal disruption or expansion of the dermis, was a feature seen in 10 o...

Image1 Image2 Image3 Image4 Case 64 A slow growing solitary reddish nodule in a 55 year old male. The nodule is 5 cm in diameter and is located on the right upper arm. Answer

Cutaneous Sarcoidosis Visit: Dermatopathology site Visit: Pathology of Cutaneous Sarcoidosis Abstract: Sarcoidosis of the skin--a dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition. J Eur Acad Dermatol Venereol.2010 Feb;24(2):125-37. Epub 2009 Aug 17. Sarcoidosis of the skin may have an extremely heterogeneous clinical presentation, so that the definitions of 'great imitator' and 'clinical chameleon' have long been used. There is, in fact, a large group of skin diseases that can enter the differential diagnosis with cutaneous sarcoid manifestations, either clinically or/and pathologically. As the clinical consequences and the prognosis of these groups of diseases are often very different, it is important to correctly plan the diagnostic workup. The diagnostic process in this case often presents a challenge as no single test is sufficiently specific, so that a certain diagnosis can be only made ...

Image 1 Image 2 Image3 Image 4 Case 63 A 35 year old male with maculopapular eruption. Patient also has history of acute lymphadenopathy and uveitis. Answer

Chondroid Syringoma Visit: Dermatopathology site Visit: Pathology of Chondroid Syringoma Abstract: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg.2010 Mar;89(3):983-5. Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented. This skin adenexal tumor is typically located on the head and neck region. The unusual location of chondroid syringoma made an accurate preoperative diagnosis difficult, and diagnosis was achieved only by excisional biopsy and histopathologic examination. Total surgical excision remains the best therapeutic option to avoid tumor recurrence and close follow-up is recommended because of a rare possibility of malignant transformation and visceral metastases. Chondroid syringoma of the hand.Scand J Plast Reconstr Surg Hand Surg.2009;43(5):291-3. Chondroid syringoma is a rare cutaneous tumour that usually arises in the head and neck region and is rarely see...