Dermatopathology Cases

Image1 Image2 Image3 Image 4 Case 55 A 55 year old woman with asharply demarcated, erythematous scaly patch on the face . Diagnosis

Ichthyosis Vulgaris Abstract: Clinical features of the nephrotic syndrome associated with ichthyosis vulgaris and analysis of related gene mutation.Zhonghua Er Ke Za Zhi.2010;48(1):44-9. OBJECTIVE: To study clinical features of 3 children who presented with nephrotic syndrome (NS) associated with ichthyosis vulgaris (IV), and to detect relationship between NS associated with IV in patients and FLG gene or NPHS2 gene. METHOD: Clinical and kidney pathological data of the 3 patients were analyzed and progress of pathologic damage in the patient kidney was observed through repeated percutaneous renal biopsy. Using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing, the diversity of the expression of NPHS2 gene in the 3 patients were analyzed, and FLG gene in the 3 patients and parts of their family members with IV was detected. RESULT: (1) The age of the 3 patients (patient 1 was a girl and patients 2 and 3 were boys) suffering from NS was 3 years and 8 mo...

Image1 Image2 Image3 Case 54 1 year old child with scaling on the extensor surfaces of the extremities. Answer

Immunohistochemistry: Cytokeratin20 Merkel Cell Carcinoma Visit: Dermatopathology site Visit: Pathology of Merkel Cell Carcinoma Abstract: New insights into merkel cell carcinoma. Adv Anat Pathol. 2010 May;17(3):155-61. Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine and epithelial differentiation. Recently, the Merkel cell polyomavirus has been implicated in the pathogenesis of MCC. In addition, there have been numerous studies evaluating the histologic and immunohistochemical characteristics of MCC as they relate to diagnosis and prognosis. The purpose of this paper is to review the most salient and clinically relevant updates in the pathogenesis and histologic features of MCC. Specific attention is given to the clinic...

Image 1 Image2 Image3 Image4 Case 53 A 74 yeare old woman with a nodule on the head. Answer