Dermatopathology Cases

Subcutaneous Panniculitis-like T-Cell Lymphoma Visit: Dermatopathology site Abstract: Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas.Arch Pathol Lab Med.2009 Feb;133(2):303-8. Subcutaneous panniculitis-like T-cell lymphoma is a primary T-cell lymphoma that preferentially involves the subcutaneous tissue. Although subcutaneous panniculitis-like T-cell lymphoma has been recognized as a distinctive entity in the category of peripheral T-cell lymphoma in the World Health Organization classification, its diagnostic criteria has been redefined by the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for primary cutaneous lymphomas. Subcutaneous panniculitis-like T-cell lymphoma is now restricted to primary cutaneous T-cell lymphoma expressing alphabeta T-cell rec...

Image 1 Image2 Image3 Image 4 Case 43 A subcutaneous, tender nodule, on the left leg, of a 45 year of female. Answer

Lupus Panniculitis (Lupus Profundus) Visit: Dermatopathology site Abstract: Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides.Semin Cutan Med Surg.2007 Jun;26(2):66-70. The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of erythematous nodules on the lower extremities. However, the histopathologic study of panniculitis is difficult because of an inadequate clinicopathologic correlation and the changing evolutive nature of the lesions. In addition, large scalpel incisional biopsies are required. From histopathologic point of view, all panniculitides are somewhat mixed because the inflammatory infiltrate involves both the septa and lobules. However, nearly always the differential diagnosis between a mostly septal and a mostly lobu...

Image 1 Image 2 Image3 Image 4 Image 5 Case 42 A 50 year old female, with multiple large indurated plaques and nodules, on the upper extremities. Answer

Fibrous Papule of the Face (Fibrous Papule of the Nose) Visit: Dermatopathology site Abstract: Solitary Oral Fibromas of the Tongue Show Similar Morphologic Features to Fibrous Papule of the Face: A Study of 31 Cases. Am J Dermatopathol. 2010 Apr 24. The morphologic similarities between fibrous papules of the face and multiple oral fibromas were mentioned long ago, mainly in the context of phakomatoses. Both lesions have been considered to be different types of angiofibromas. Nonetheless, this interpretation is not accepted by all authors. We tried to investigate if solitary oral fibromas also share morphologic features with fibrous papules of the face. For this purpose, we designed a retrospective study retrieving 31 fibromas of the tongue from 30 different patients and studied a control group of 20 fibrous papules of the face from 20 different patients. From the oral fibromas, 15 lesions presented as dome shape, whereas 16 lesions presented as polypoid. Lesion size varied between 2 a...