Dermatopathology Cases

Image1 Image2 Image2 Image3 Image4 Case 106 A 28 year old female with a reddish brown nodule on the left leg. Diagnosis

Immunostaining, staining reveals that the epithelial cells are positive for cytokeratin , estrogen receptor (ER) and progesterone receptor (PR). PR (Progesterone Receptor):Positive ER (Estrogen Receptor): Positive Cytokeratin: Positive Diagnosis: Cutaneous Ciliated Cyst Visit: Dermatopathology Site Visit: Pathology of Cutaneous Ciliated Cyst Abstract: Cutaneous ciliated cyst of the right lower leg. Pathol Int. 1999 Apr;49(4):354-7. A 23-year-old Japanese woman with a cutaneous ciliated cyst on her right lower leg is reported. A subcutaneous cyst, measuring 2.5 cm in diameter with papillary projections into the lumen, was lined with ciliated cuboidal to columnar epithelia with partial stratification, histologically. These lining cells did not produce mucin. Immunohistochemically, the ciliated lining cells of the cyst were diffusely positive to epithelial membrane antigen and cytokeratin. In addition, positive immunoreaction with anti-desmin monoclonal antibody was observed in the body

Image1 Image2   Case 105 A 38 year old female with a cystic lesion on the lower part of the left leg. The lesion is 2.5cm in diameter. Diagnosis

Allergic Granulomatosis (Churg-Strauss Syndrome) Visit: Dermatopathology Site Visit: Allergic Granulomatosis (Churg-Strauss Syndrome) Visit: Pathology of Churg-Strauss Syndrome) The three major microscopic features of Allergic Granulomatosis are: 1) Necrotizing vasculitis 2) Tissue infiltration by eosinophils 3) Extravascular granulomas It should be noted that the 3 features mentioned above do not always coexist. In Case No 104 there is small-vessel necrotizing vasculitis together with extensive tissue infiltration by eosinophils. No granulomas were present in the multiple sections taken. Hence in this case detailed clinical history played a very important role to reach the final diagnosis.

Image 1 Image2 Image 3 Image4 Image5 Image6 Case 104 A 42 year old female with history of asthma and allergic rhinitis. There is marked peripheral blood eosinophilia. Erythemous macules are present on the extremities. Biopsy from the skin lesion. Diagnosis